Rye et al. (2012) identified significant associations at several loci, including CAPN14, GALNT14, BPIFA3 and BPIFA1, identifying novel candidate genes for further analysis. Interestingly, a mouse model of BPIFA1 was recently shown to demonstrate an increased susceptibility to OM (Bartlett et al., 2015). In a second GWAS study (Allen et al., 2013), a novel susceptibility locus on chromosome 2 was identified, with the relevant SNP lying in the intergenic region between CDCA7 and SP3. The gene discussed is CAPN14; the disease is ocular melanoma.