In breast cancer, PD-L1 was upregulated in 20 % of cases and was related to poor-prognostic features such as tumor size, high grade, estrogen and progesterone negativity, Her2/Neu positivity and higher rates of cell proliferation, although upregulation of PD-L1 was not associated with survival of patients in this study [21]. The gene discussed is CD274; the disease is breast carcinoma.