In addition, our previous study demonstrated that CDK11p58 inhibited ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling [15] and also we found breast cancers transfected with CDK11p58 grew slowly compared with the control cell lines, so we speculated that CDK11p58 might inhibit the growth of breast cancer. This evidence concerns the gene ESR1 and breast carcinoma.