For example, matrine, which is currently used in the clinic to treat LC [34] and HCC [35, 36], inhibits cell proliferation, promotes cell differentiation and apoptosis, reduces cancer cell invasion and metastasis, and inhibits HCCR/LETMD1 mRNA and protein expression in cultured HCC cells [37]. The gene discussed is LETMD1; the disease is hepatocellular carcinoma.