We examined the expression of RILP in different breast cancer cell lines, and found that the expression of RILP is lower in the highly invasive cells, such as BT549, Hs578t and MDA-MB-231 compared with less-invasive cell lines such as MCF7, SKBR3 and ZR75.1 (Figure 1a), suggesting downregulation of RILP is potentially associated with the increased invasion of breast cancer cells. The gene discussed is RILP; the disease is breast carcinoma.