RAB25 and cancer: For examples, Rab25 is overexpressed in breast and ovary caners,6 and recent investigations suggest that Rab25 is also related to other cancers.7, 8, 9 Arf6 is a vital regulator for the invasive activity of breast cancer cells.10 Disordered membrane trafficking is emerging as an important property during tumorigenesis, thus the membrane trafficking machineries are potential therapeutic targets for cancer treatment.