TNFSF10 and glioblastoma: In glioblastomas several resistance mechanisms are known including high expression of TRAIL-decoy receptors,26 epigenetic silencing of the TRAIL receptor DR4,15 overexpression of the anti-apoptotic protein FLICE-inhibitory protein (FLIP),27 and altered expression of the Bcl-2 family members, which negatively interfere with TRAIL-induced apoptosis.28, 29