We previously reported that Notch1 signaling promotes survival of glioblastoma cells via epidermal growth factor receptor (EGFR)-mediated induction of anti-apoptotic Mcl-1.13 This EGFR-dependent regulation of the anti-apoptotic Mcl-1 protein results in a decreased susceptibility to activators of both the extrinsic and intrinsic apoptotic pathway which can be overcome by Notch1 inhibition. The gene discussed is NOTCH1; the disease is glioblastoma.