This is in contrast to the majority of anti-apoptotic signaling pathways deregulated in glioblastomas including the intrinsic anti-apoptotic action of the Notch1 pathway itself,13 which protect cancer cells from apoptosis induced through inherent stresses such as oncogenic stress or hypoxia which are pushing them closer to the edge of dying.53 The gene discussed is NOTCH1; the disease is glioblastoma.