Several studies showed that c-Myc induces the proliferation, migration and invasion of NPC cells.53, 54, 55 In addition, c-Myc was reported to promote radioresistance in a stem cell-like population of NPC cells.19 Mounting evidence indicates that c-Myc expression in the tumor may be an important strategy for designing appropriate treatment, using lower drug dosages and overcoming drug resistance and drug-related toxicity.56, 57, 58, 59 Hence, many investigators and international pharmaceutical companies have turned to identifying c-Myc inhibitors to cure cancers. This evidence concerns the gene MYC and cancer.