MYC and neoplasm: FBP1 regulated the expression of c-Myc by binding to the FUSE in the c-Myc promoter region at 1.5-kb upstream of the transcription start site.22 A number of reports demonstrate that FBP1 is involved in the regulation of cellular processes, including gene expression, differentiation and apoptosis.22, 34, 38, 60, 61 Many studies suggest that FBP1 is a proto-oncogene, because there is a close relationship between FBP1 expression and tumor development.