MYC and nasopharyngeal carcinoma: c-Myc is located at 8q24.21, and encodes a transcription factor that has essential roles in cell proliferation, cell growth, differentiation and apoptosis.45 It has been reported that c-Myc is an oncogene and transcription factor involved in the tumorigenesis of multiple cancers.46, 47, 48, 49, 50, 51 Fan, CS et al52 indicated that c-Myc overexpression is a frequent genetic abnormality in NPC.