AIFM1 and cancer: AIF and endoG are important factors for mitochondrial apoptosis and can mediate caspase-dependent and -independent cell death.3, 37 We then used AIF siRNAs (si AIF), endoG siRNAs (si endoG), or both siRNAs (si AIF/endoG) to decrease AIF and endoG expression in cancer cells (Figures 4b and c).