Previous studies have revealed that Akt activation could inhibit tBid appearance and Bid-induced apoptosis.42, 43 Moreover, a previous study showed that genistein induced apoptosis through the Akt pathway in anaplastic large-cell lymphoma.44 Thus, we speculated that Akt is the upstream apoptotic regulator in our experiments. Here, AKT1 is linked to anaplastic large cell lymphoma.