RUNX2 (Runt-related transcription factor 2) is one of the RUNX family members implicated in the induction of osteoblast differentiation and bone formation.6 Recently, we have found for the first time that RUNX2 attenuates p53/TAp73-dependent proper DNA damage response in p53-proficient human osteosarcoma-derived U2OS cells.7, 8 On the basis of our results, RUNX2 prohibited the transcriptional as well as pro-apoptotic activity of p53 through the complex formation with p53 in response to adriamycin (ADR). This evidence concerns the gene RUNX2 and osteosarcoma.