NOS2 and cancer: These include inhibin A which may contribute to cancer-associated cachexia,27 nitric oxide synthase-2 (NOS2) which may enhance resistance to apoptosis,28 CCNE which encodes cyclin E1, and Nedd4-binding protein 2-like 1 (N4BP2L1) which is a Bcl3-binding protein (Figure 4f) whose upregulation may lead to increased sensitivity to platinum.29, 30