TP53 and breast carcinoma: In order to further generalize our findings, we tested the ability of p53 to activate the MVA metabolism-related genes in human adenocarcinoma breast cancer cell lines MCF7 with wild-type p53 and MDA MB 231 with p53 mutant (R280T)17 and in human adenocarcinoma colon cancer cell lines HCT116 with wild-type p53 and SW620 with p53 mutant (R273H).17 In accordance with human glioblastoma cells used in this study, levels of six genes were increased in cell lines with wild-type p53 compared with cell lines with mutant p53 (Supplementary Data,Supplementary Figure S1).