Another hallmark of MDR+ tumor cells is the increased prenylation and activity of GTP-binding proteins, which are also dependent on the rate of the MVA pathway activity.35 In summary, our results show that p53 is an essential transcription factor for the regulation of MVA pathway, and further studies will be necessary to determine the mechanism by which p53 regulates the MVA pathway enzymes. Here, TP53 is linked to neoplasm.