PRKN and Parkinson disease: These two proteins associate with PD pathogenesis and regulate mitochondrial homeostasis, protein homeostasis, and autophagy in C. elegans and other systems.6, 37, 38, 39, 40, 41 First, to determine whether metabolite susceptibility depends on UPS-dependent Parkin, we depleted pdr-1 (the C. elegans homolog) cell-autonomously in α-synuclein-expressing dopaminergic neurons in conjunction with the metabolite and/or MG132.