Moreover, the silencing of miR-205 expression in T24 cells with imbalanced H3K4me3 and H3K4me3 was reversed in T24 cells with knockeddown HOTAIR expression (Figure 7e), suggesting a direct role of HOTAIR on the regulation of miR-205 expression via the recruiting PRC2 and LSD1 in bladder cancer. Here, HOTAIR is linked to urinary bladder cancer.