Human HOTAIR, a 2.2 kb lncRNA transcribed from the HOXC locus, binds both to the PRC2 and the LSD1 complexes, and it was recruited to hundreds of genomic sites to promote coordinated H3K27 methylation and H3K4 demethylation, respectively.33, 34 There was only one report by Yan et al.,35 showing that HOTAIR is upregulated in bladder cancer, and it can be used as a prognostic marker to predict the recurrence in stage Ta/T1 bladder cancer. This evidence concerns the gene HOTAIR and urinary bladder carcinoma.