This bifunctional character of HOTAIR could be required for coordinating histone modifications of H3K27 methylation and H3K4 demethylation for epigenetic gene silencing in the metastatic processes.13, 14 In addition, recent studies have shown that HOTAIR could modulate other classes of non-coding RNAs, including miRNAs,15 for example, Wiklund et al.16 study reported that miR-200 and miR-205 were silenced in bladder cancer, and DNA hypermethylation as possible prognostic markers, but the interaction between HOTAIR and miR-205 has not been reported before. The gene discussed is HOTAIR; the disease is urinary bladder carcinoma.