Several studies have demonstrated that one of its members, miR-205, can regulate the proliferations of several types of cancer cells: targeting ZEB1 (zinc finger E-box binding) and Ubc13 in breast cancer cells,23 ZEB2 in renal cell carcinoma,24 phosphatase and tensin homolog in endometrial cancer Ishikawa cells,25 Yin Yang 1 in gastric cancer cells,26 Ezrin and Lamin A/C in ovarian cancer,27 just to name a few. The gene discussed is UBE2N; the disease is hereditary clear cell renal cell carcinoma.