Our observation that the apoptotic pathway of CSPG4 positive tumor cells is activated by r28M-mediated PBMC is in accordance with Bäuerle and Stein, who state that connecting a tumor cell with an effector cell through an immunologic synapse mediated by a bispecific antibody causes cytolysis of the tumor cell [16, 39]. The gene discussed is CSPG4; the disease is neoplasm.