The detection results of IGF-IR in the 4 fractions of bone marrow nucleated cells, namely CD34+ cells, erythroid lineage cells (CD235a-positive), T lymphocytes (CD3-positive), and B lymphocytes (CD19-positive), from 55 MDS patients showed that IGF-IR expression in the CD34+ cells from the MDS patients was significantly higher than that in the cells from the normal controls (54.0 vs. 4.5%; P<0.0001) (Fig 1E and 1I). This evidence concerns the gene GYPA and myelodysplastic syndrome.