Similar to that seen in ECC-1 cells, TM treatment (30 μM, 24 h) under normoxia effectively reduced the levels of HIF-1α in IGROV-1 and 2008 human ovarian cancer cells (Fig. 1B), suggesting that the effects of TM on levels of HIF-1α are not cell-specific events. Here, HIF1A is linked to ovarian cancer.