In addition, Ly-GDI associates with CARD9, a caspase-recruitment domain (CARD)-containing protein, in phagosomes after bacterial and fungal infection, and binding of CARD9 suppressed LyGDI-mediated inhibition of the GTPase Rac1, thereby leading to bacterial killing in macrophages [26]. The gene discussed is ARHGDIB; the disease is fungal infectious disease.