SOD1 and inflammatory bowel disease: Once the amount of oxidant production exceeds the capacity of endogenous antioxidant defense, associated with an increase in MAD and a decrease GSH and SOD, the gut would potentially be subject to injury [41, 42].Oxidative stress, as important as inflammatory affect, participated in the pathogenesis of inflammatory bowel disease, has been proposed to be related to the recruitment and activation of neutrophils infiltration of the inflamed colon mucosa during acute inflammation[32].