We observed a significant (p < 0.01) upregulation of let-7a pri-miRNA (>2.5-fold) in tumors treated with NP-siDCLK1 compared with control and NP-siSCR-treated tumors (Figure 5B), indicating that DCLK1 knockdown induces miRNA let-7a in tumor xenografts. Here, DCLK1 is linked to neoplasm.