To begin to investigate the role of infDCs derived from CCR2-expressing CD11b+Ly6Chi cells in the dominant ET cell response, we infected Ccr2-/- or C57BL/6 control mice IV with mE, and measured several parameters of the infection and immune response (mouse survival and weight, bacterial CFU and numbers of CD11b+Ly6Chi and ET cells in spleens). This evidence concerns the gene CCR2 and infection.