To explore this hypothesis, we performed a hierarchical clustering of both endemic and sporadic cases on TCF3 target genes (previously reported in Schmitz et al.[19]) and we demonstrated that the first bifurcation of the dendrogram classifies the samples into EBV-positive and EBV-negative BL independently on the specific subtype with an accuracy of 96% (45/47). This evidence concerns the gene TCF3 and Burkitt lymphoma.