RHOA, which belongs to the Ras homolog family, is a small GTP-ase protein recently found to be mutated in three tumors associated with EBV infection, namely peripheral T-cell lymphoma (where it relates to follicular helper T-cells[65–67]), diffuse gastric carcinoma[68] and paediatric sBL[28]. This evidence concerns the gene RHOA and Epstein-Barr virus infection.