However, addition of PGE2 counteracted the impact of ω-3 PUFAs on Akt phosphorylation and cyclin D1 expression, suggesting that regulation of COX-2 expression and PGE2 production played a major role in ω-3 PUFAs-mediated growth inhibition of endometrial cancer. The gene discussed is CCND1; the disease is endometrial cancer.