DKK3 and non-small cell lung carcinoma: In parallel, we also found that miR-582-3p expression was closely inversely correlated with DKK3 and SFRP1 protein levels in 9 cases of NSCLC tissues with unmethylated DKK3 and SFRP1 promoters (Supplementary Fig. 7a–c) Furthermore, significant inverse correlations of miR-582-3p with DKK3 and SFRP1 were observed in specimens with methylated DKK3 and SFRP1 promoters (Fig. 7c).