Due to tight correlation of high miR-582-3p with low DKK3 and SFRP1 expression in NSCLC specimens harbouring either unmethylated or methylated DKK3 and SFRP1 promoters, aberrant expression of miR-582-3p may serve as a novel mechanism underlying the activation of Wnt/β-catenin signalling that is equally as important as methylation in this cancer type. The gene discussed is DKK3; the disease is cancer.