In NSCLC, members of the miR-29 family have been reported to reduce the expression of two DNA methyltransferases, namely, DNMT3A and DNMT3B, to abrogate WIF-1 promoter methylation, consequently upregulating WIF-1 expression and leading to Wnt signalling suppression. The gene discussed is WIF1; the disease is non-small cell lung carcinoma.