APC and colonic neoplasm: However, unlike in colon cancer, mutations in β-catenin and APC genes appear to be uncommon in NSCLC according to previously reported studies20, 21 and according to The Cancer Genome Atlas (TCGA) data sets, suggesting that epigenetic mechanisms might be involved in maintaining constitutive activation of Wnt/β-catenin signalling cascades in NSCLC cells.