TGS1 and Hyperglycemia: Recently, we have shown that 1) PIMT deficiency in the liver impaired hepatic gluconeogenesis 2) ERK2-mediated phosphorylation of PIMT at Ser298 is essential for hepatic gluconeogenesis 3) Hyperthyroidism induces PIMT Ser298 phosphorylation and enhances PEPCK expression resulting hyperglycemia in rats49.