Consistent with the data from cultured cells, infection with Ad-PIMT Ser298Asp but not Ad-PIMT Ser298Ala suppressed GLUT4, MEF2A, MEF2D (Fig. 8a,d,e) expression while up-regulating PGC1-α, HDAC5 and MEF2C expression in the rat skeletal muscle tissue (Fig. 8b,c,f). This evidence concerns the gene MEF2A and infection.