Of the 16 patients with severe organ involvement, 9 (56.2 %) had AST >1000 IU/L and/or ALT >1000 IU/L, 9 (56.2 %) had serum creatinine ≥3 times above baseline, 1 (6.2 %) had myocarditis, and 1 (6.2 %) had encephalitis. This evidence concerns the gene GPT and viral encephalitis.