TNF and breast cancer: BC cells secrete PTHrP (parathormone-related protein) [5], in addition to other soluble factors that are normally secreted by stromal and other marrow cells to regulate the OC maturation, and have M-CSF (macrophage-colony stimulating factor), IL (interleukin)-1β, IL-8, IL-6 and TNF-α (tumor necrosis factor) functions [6–8].