For instance, hyperactivity of the phosphoinositide 3-kinase (PI3K)/Protein Kinase B (Akt)/mammalian target of Rapamycin (mTOR) pathway, is a molecular hallmark of accelerated proliferation and tumor progression in BC cells, since intrinsic molecular aberrations recur in approximately 40 % of patients with metastatic skeleton disease [11]. This evidence concerns the gene PIK3CA and breast cancer.