Although it has been reported that both MDA-MB-231 and MCF7 may acquire resistance to everolimus [49], in our hands, the minor intracellular content of pro-OC factors, namely M-CSF, IL-6, IL-1β, TNFα and MIP-1α, induced by NFkB in Everolimus-treated BC cells emphasizes the interactive negative regulation between these pathways. The gene discussed is IL1B; the disease is breast cancer.