The bone resorption markers at 6 and 12 weeks revealed a significant decrease in patients treated with Everolimus [16], and this beneficial effect on bone health was attributed to the reduced OC function associated to the general anti-tumor activity induced by Everolimus on BC cells, as well as to a direct mTOR inhibition in BC-stimulated OCs, since this pathway drives their functional maturation [17]. This evidence concerns the gene MTOR and breast cancer.