ACP5 and neoplasm: Finally, Fig. 6b and c shows the histology pattern of tumor engraftment by MDA-MB231 cells of the right tibia of a SCID mouse, displaying devastation of the bone structure, massive infiltration of the spongy bone, and a number of TRAcP+ cells, so functional OCs, in close contact with the tumor cells and juxtaposed to the cortical bone.