CXCL8 and Shock: Like many other chemoattractants, IL-8 induces re-arrangement of cytoskeleton, changes in intracellular Ca2 levels, activation of integrins, exocytosis of granule proteins, and respiratory burst.29There are some chronic inflammatory diseases, such as psoriasis, rheumatoid arthritis, as well as pulmonary diseases, in which IL-8 is overexpressed, and high levels of IL-8 are also seen after septic shock or systemic administration of endotoxin.30-32