ERBB2 and breast neoplasm: HER2-amplified breast tumors promote aggressive disease, with poor prognosis14, -16 due to its rapid proliferation and spreading.17,18 These tumors are reported in overweight/obese women, which exhibit enhanced disease spreading in relation to non-obese patients.8 In this case, the excessive bioavailability of lipids seems to favor the epithelial transformation of cells into HER2-amplified neoplastic cells.