Among others, the 5-Hydroxytryptamine receptor channel type 3 (5-HT3R), which is widely expressed throughout the brain and in peripheral organs (e.g., the gastrointestinal tract), has been extensively studied from a structural and functional point of view.[36] The 5-HT3R is involved in many neurophysiological functions,[37,38] like nervous transmission regulation, pain processing, peristalsis and in some pathological states[38] like chemotherapy-induced nausea and vomiting and various psychiatric disorders. Here, HTR3A is linked to psychiatric disorder.