In fact, pregnancy and adolescence are both conditions associated with changes to the levels of immune mediators in the lower genital tract.10, 12 Typically, bacterial vaginosis is associated with increased cervicovaginal levels of interleukin (IL)-1 beta, but in pregnant women the levels of IL-6 and IL-8 are also elevated in the presence of bacterial vaginosis.13, 16 There is still a lack of information in the literature regarding the immune response to bacterial vaginosis in adolescents. This evidence concerns the gene IL1B and bacterial vaginosis.