However a small proportion of patients (e.g. people with diabetes) with eGFR>60mL/min/1.73m2 with stage 1 or 2 CKD do either spontaneously revert to normalbuminuria or do so under the influence of blood pressure (BP) control, specifically RAAS (Renin-angiotensin-aldosterone system) blockade (with ACE-I or ARB). The gene discussed is ACE; the disease is chronic kidney disease.