In order to test the specificity of the HspB2 Y2H interactome, the interactome was compared to the recently published HspB1 (Hsp27) interactome in which 228 binding partners were identified by Katsogiannou et al. from large-scale Y2H screens of testis and Hela cancer cell libraries [35]. The gene discussed is HSPB2; the disease is cancer.