For a list of 16 autoantibodies that were detected by Euroline ANA Profiles in our patients when they underwent active SLE, specific autoantibodies against these nuclear components were significantly correlated; more importantly, simultaneous reactivity to these antibodies was prevalent and positively correlated to LN development, with the odds ratio of 5.529. This evidence concerns the gene BTG3 and systemic lupus erythematosus.