IGF2 and cancer: Our evolving data identify the importance of the intercellular IGF-2/IGF-2R system in cancer cell communication with the TME showing that: (1) macrophages and fibroblasts but not ECs migrate towards cixutumumab-treated cancer cells or CM obtained from the cancer cells; (2) IGF-2R expression is observed in macrophages and fibroblasts but not in HUVECs; and (3) the ability of cancer cells to chemoattract stromal cells is inhibited by silencing IGF-2 or IGF-2R expression in cancer cells or stromal cells, respectively.