TNFα offers neuroprotection as reflected in the levels of calbindin and superoxide scavenger (Watters and O'Connor, 2011), the up-regulation of potassium channels to block NMDAR-related excitotoxicity (Carlson et al., 1999; Dolga et al., 2008), the regulation of NFκB-related neuroprotection (Taoufik et al., 2011) and the reduction of AD pathology by suppressing amyloid induced Cdk5 activity and tau phosphorylation (Orellana et al., 2007). This evidence concerns the gene MAPT and Alzheimer disease.