Interestingly, however, various factors now recognized as being REST dependent, such as miRNAs (including miR-9/9* and miR-132, which operate reciprocally to REST) and ncRNAs, have been proposed to play significant roles in Alzheimer’s disease (Schonrock et al., 2012; Lau et al., 2013; Wu et al., 2013). This evidence concerns the gene REST and Alzheimer disease.