KCNA3 and Dravet syndrome: Similar to ethosuximide, a reduction in regenerative burst discharges associated with neuronal T-type calcium currents could be the underlying mechanism for dimethadione in DS mutants; however, it is worth noting that T-type channel blockers ethosuximide and flunarizine were not similarly effective (Baraban et al. 2013; this article), and that dimethadione can cause arrhythmia owing to blockade of cardiac human ether-a-go-go-related gene potassium channels (Azarbayjani and Danielsson, 2002; Danielsson et al., 2007).