NES and Anxiety: For example, when the pro-apoptotic protein Bax is inducibly expressed in Nestin-expressing adult neural stem cells, inhibition of adult neurogenesis presents an anxiety-like phenotype (elevated-plus maze, dark/light box, and predator-avoidance tests) although it had no effect on depression (forced-swim and novelty-suppressed feeding tests) (Revest et al., 2009).