SFPQ and neurodegenerative disease: One highly represented protein in the PHF8−TIP60 interactome is the RNA polymerase II-associated splicing factor PSF (Emili et al., 2002; Rosonina et al., 2005), which is reported to play a key role in neuronal development (Lowery et al., 2007), alternative splicing (Kim et al., 2011), and is found to be dysregulated in neurodegenerative diseases (Ke et al., 2012).