CXCL8 and mastitis: The presence of high numbers of suppressor CD8+ T-cells compared to CD4+ T-cells significantly suppresses lymphocyte IRs and recruitment [78, 86]; and in addition to unstable expression and release of inflammatory inducers (IL-1β, IL-8, and TNF-α) [17, 86, 114, 131, 134, 165, 239, 329], compromised expression and release of inflammatory cytokines (depressed IL-2 and C5a levels) [17, 86, 114, 239, 350] and unstable release of anti-inflammatory IL-10 [114] could greatly reflect and provide explanation for the suppressive nature of mastitis-causative Staph.