A 12-week study researching the effects of resistive and aerobic exercise on the plasma concentrations of RBP-4 in individuals diagnosed with T2DM showed that the change in RBP-4 concentration was significantly greater (P < 0.05) in the group that performed resistance exercise (−16.4 μg/mL) than the group that performed aerobic (walking) exercise (−2.3 μg/mL), or the control group (no exercise) (1.2 μg/mL) [29]. This evidence concerns the gene RBP4 and type 2 diabetes mellitus.