It has been shown that elevated TUBB3 and/orTOPIIA expression levels in gastric, non-small celllung cancer (NSCLC), ovarian, cervical, salivarygland and breast cancersis associated with a poorerresponse to anticancer agents that bind to anti-tubulinagents and poorer prognosis or reduced survivalin patients. The gene discussed is TUBB3; the disease is non-small cell lung carcinoma.