HNF1B and Familial prostate cancer: The first report of HNF1β associated with prostate cancer risk was in a genome-wide association study (GWAS) searching for sequence variants in 1501 Icelandic men with prostate cancer and 11,290 controls, and the variant, rs4430796, in HNF1β at chromosome 17q12 was the earliest loci to be discovered for prostate cancer [6].