We compared rounded-contractile A375M2 melanoma cells with more elongated ROCK-inhibited A375M2 cells (treated with H1152, Y27632, or Fasudil for 24 hours) (P = .0047, P < .001, P < .001) or with intrinsically less contractile A375P cells, with higher Rac1 activity (7,8) (Figure 1, B and C). The gene discussed is RAC1; the disease is melanoma.