In SHR ventricular remodelling, cardiac hypertrophy is associated with an increase in fibrosis [49, 50], and it has been shown that endogenous AngII, mediated by AT1 receptors, plays a role in the formation of fibrosis e.g. by stimulating of TGF-β1-synthesis [7, 8, 40]. The gene discussed is AGTR1; the disease is cardiac hypertrophy.