Similarly, in Unc93b13D mutant mice, in which a single nucleotide mutation in Unc93b1 results in deficient TLR3, TLR7 and TLR9 responses19, the titer of polyreactive antibodies at 14 days before infection was about 1,800 and increased to 4,000 at 7 days after infection (Fig. 3C). The gene discussed is TLR9; the disease is infection.