C9orf72 and Atrophy: In the separate VBM subanalysis of patients with C9orf72 expansions contrasted with other FTLD patients showing altered pain or temperature responses (Table 3 and Fig. 1), symptoms due to C9orf72 mutations were significantly associated with atrophy of right posterior thalamus (and borderline significant also for left posterior thalamus; P < 0.05FWE within the prespecified anatomical region of interest).