C9orf72 and early-onset autosomal dominant Alzheimer disease: More specifically, we hypothesized an association of insular atrophy with symptoms across syndromes (Peyron et al., 2000; Craig, 2002; Zhou and Seeley, 2014); and partly separable neuroanatomical associations, targeting thalamus in C9orf72 mutations, more anterior cortical regions in other FTLD subgroups and more posterior somatosensory cortical association areas in Alzheimer’s disease (Cole et al., 2006; Chan et al., 2009; Downey et al., 2014; Lee et al., 2014).