As expected, the upstream 1 kb region of the MUPCDH promoter was hypermethylated in both ADPKD renal tissue and WT9-7 ADPKD cyst-lining epithelial cells compared with non-ADPKD renal tissue and human renal cortical epithelial (HRCE) cells (Fig. 1). The gene discussed is CDHR5; the disease is autosomal dominant polycystic kidney disease.