In late stage CRC group, 14 proteins were up-regulated (hemoglobin subunit beta, human retroviral like aspartic protease 1, human uncharacterized protein CFH, human PRO2275, human uncharacterized protein LOC134121, APOE, human vitamin K dependent protein C, protein rogdi homolog, inter-alpha-trypsin inhibitor heavy chain H4, alpha 1-antitrypsin, human serum amyloid, prothrombin, SYJN2 and APOA1) and 4 proteins were down-regulated (PCOLCE1, truncated beta globin fragment, keratins and human isoform 6 of protein ZNF365) (Table 1). The gene discussed is HBB; the disease is colorectal carcinoma.