In the early stage CRC group, 8 proteins were up-regulated (truncated beta globin fragment, albumin, complement C4A, protein rogdi homolog, ficolin collagen fibrinogen domain containing 3 Hakata antigen, prothrombin, SYNJ2 and APOA1) and 2 proteins were down-regulated (GAL7 and isoform 6 of protein ZNF365). The gene discussed is ROGDI; the disease is colorectal carcinoma.