However, in a more comprehensive aspect, the combination of the Ang-2/Ang-1 and Ang-1/Tie-2 ratios with the MEDS score indicates the degree of general capillary endothelial damage and pathological condition of patients with sepsis and reflects the pathophysiological mechanism of widespread capillary endothelium and the risk of short-term mortality of patients in early sepsis. The gene discussed is ANGPT1; the disease is Sepsis.